Do you want more strength and general vitality?

The purpose of testosterone replacement is to relieve the signs and symptoms of hypogonadism with improved sexual desire and function, increased disposition, a feeling of well-being, increased vitality, increased muscle mass, decreased abdominal waist, decreased body fat , increase in bone mineral density.

Symptoms of testosterone deficiency include: declining sexual interest; difficulty in erection; lack of concentration and intellectual capacity; loss of hair; weight gain at the expense of fat; decreased muscle mass and strength; irritability and insomnia; among others. Symptoms are non-specific and can occur in conditions other than testosterone deficiency.

Testosterone is a sex hormone responsible for stimulating sperm production, favors bone density, acts on fat distribution, increases strength and muscle mass, stimulates facial and body hair, stimulates the production of red blood cells and increases libido.

Testosterone is not only important in regulating reproductive function, but it is also an important determinant of body composition in men. Although not an indication for replacement therapy, randomized clinical trials show that testosterone treatment is able to reduce fat mass and increase lean mass. In observational studies, long-term testosterone treatment has also been associated with a reduction in body weight. The mechanisms by which testosterone promotes fat loss may include effects on the differentiation and function of adipocytes (cells that accumulate fat). Recently, the randomized study by Fui et al published in the Journal of the Endocrine Society suggested that testosterone may directly inhibit leptin production in adipose tissue. This is consistent with reports that testosterone treatment suppresses leptin messenger RNA and leptin secretion from human adipose tissue.

Testosterone deficiency is common in men reaching 20% of those over 50, with an incidence of 12 new cases per 1000 individuals each year. Some are more subject to the development of testosterone deficiency such as men with metabolic syndrome, diabetes 2 and obese.

1) Mark Ng Tang Fui, Rudolf Hoermann, Mathis Grossmann; Effect of Testosterone Treatment on Adipokines and Gut Hormones in Obese Men on a Hypocaloric Diet. J. Endocr. Soc. 2017; 1 (4): 302-312. doi: 10.1210/js.2017-00062

2) Fundamental Concepts Regarding Testosterone Deficiency and Treatment: International Expert Consensus Resolutions Abraham Morgentaler, MD; Michael Zitzmann, MD. Mayo Clin Proc. n July 2016;91(7):881-896 n http://dx.doi.org/10.1016/j.mayocp.2016.04.007

3) Thomas G et al. Harmonized Reference Ranges for Circulating Testosterone Levels in Men of Four Cohort Studies in the United States and Europe. J Clin Endocrinol Metab (2017) 102 (4): 1161-1173.